When To Avoid Sildenafil-Based Generic Viagra

When To Avoid Sildenafil-Based Generic Viagra

Ever since the Pfizer lost the patent of Sildenafil-based Viagra, the number of generic-equivalence has surged up massively.

Earlier, the two factors, i.e., high prices and difficult availability of Viagra over the counter had controlled the side-adversaries of the drug.

Most men would confer with the doctor before fixing the ideal dosage— as they would fear the reaction of the drug in the body.


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But with the easy availability over the counter and extremely affordable rates; the onus is upon us— the responsibility is ours that we understand all the contraindication related to Sildenafil, and we don’t abuse our body from these drugs.

The contraindication of Sildenafil means that your body can’t take the said drug because you already have other prescribed medications which might chemically cross-react and yield unwanted effects.

So, in the given piece, we shall unravel some of the situations when you should strictly avoid the use of Sildenafil.

  • When you are taking nitrates

When you are suffering from extreme chest pain (Angina), get sporadically hit by the Angina attack, or have heart-related issues; your doctor might prescribe you nitrate (Nitroglycerine).

When you intake Sildenafil through the generic-replica of Viagra, the chemical reacts with these nitrate medicines to potentiate hypotensive situation which often contributes to low blood pressure.

Although the effect of Sildenafil Citrate gets diluted after 5 to 6 hours, and the plasma level of it is at lowest after 24 hours; you can’t judge whether you can administer nitrate after that.

So, when patients take generic-sildenafil, it is unknown when to take nitrate so that you don’t develop hypotensive situations.

  • When you are on HIV-medication

When you have HIV, your doctor is most likely to prescribe the drugs which impede the action of protease and non-nucleoside reverse transcriptase enzymes.

These enzymes have earned notoriety in creating a favorable environment for the HIV virus to create their copies which fasten their dissemination process in the body.

When you ingest protease and non-nucleoside reverse transcriptase inhibiting drugs in the body, you actually stop these enzymes from working their heart out in worsening your condition.

CYP3A4 enzyme in the liver metabolizes these anti-HIV drugs, but the catch is— the same catalyst also metabolizes Sildenafil citrate.

Hence, CYP3A4 enzyme becomes too busy to metabolize Sildenafil which as a result leaves high-traces of Sildenafil in the bloodstream.

As a result, the effect of Sildenafil stays longer than the anticipated, and more importantly, it poses dangerous side-effects.

  • When you already intake Hypertensive drugs

Pulmonary Hypertension is a condition when the arteries of the lungs get clogged by plaque which later leads to short breath, tiredness, chest pain, etc.

In such cases, your doctors may recommend you riociguat— a drug which stimulates soluble guanylate cyclase (sGC).

When you intake Sildenafil-ladened generic Viagra in conjunction with Riociguat, the drugs may interact and may produce a doubling effect.

The doubly-effect of the drug generates hypotensive consequences where you’d feel dizzy, tired, loss of consciousness, and at the worst case, you may also get a cardiac arrest.

  • When you are resorting to other ED-drugs

It’s understandable that with the multiple ED-medication, we want to try all the drugs to find the best suitable chemical for us.

If you are currently using Tadalafil, Avanafil, Udenafil, Vardenafil, or similar ED-drugs; you should avoid Sildenafil Citrate at any cost.

When already intake other ED-drug, your PDE5 levels are already saturated.

Taking Viagra with any of the mentioned drugs would aggravate your condition by exposing you to the significant threats of side-effects.

It’s the same as taking the drug twice when you are advised to take it once.

So, you have to see if you are not overdosing yourself— and if you do— you are to be blamed and no one.

It is advised to stay honest about your medical history with your doctor because your honesty would decide if you need generic-Sildenafil for your ED-issues.