Carditrex 2.5 mg
Carditrex 2.5 mg injection is used alone or together with other medicines to treat several types of cancer, such as breast, head and neck, lung, blood, bone, lymph node, and uterus cancers.
Carditrex 2.5 mg
Description Of Carditrex 2.5 mg
Carditrex injection is used alone or together with other medicines to treat several types of cancer, such as breast, head and neck, lung, blood, bone, lymph node, and uterus cancers.
Carditrex is also used to treat adults with severe rheumatoid arthritis and children with polyarticular juvenile idiopathic arthritis who had other treatments that did not work well. It is also used to control symptoms of severe psoriasis in adults who have not been helped by other treatments.
Carditrex belongs to the group of medicines known as antineoplastics (cancer medicines). It blocks an enzyme that is needed by cells to live. This interferes with the growth of cancer cells, which are eventually destroyed by the body. For patients with arthritis or psoriasis, Carditrex may work by improving the immune system.
Carditrex 2.5 mg Chemical Name
Carditrex 2.5 mg Manufacturer
- Cadila Pharmaceuticals Ltd
Uses of Carditrex 2.5 mg
Methotrexate is used to treat severe psoriasis (a skin disease in which red, scaly patches form on some areas of the body) that cannot be controlled by other treatments. Methotrexate is also used along with rest, physical therapy, and sometimes other medications to treat severe active rheumatoid arthritis (RA; a condition in which the body attacks its own joints, causing pain, swelling, and loss of function) that cannot be controlled by certain other medications. Methotrexate is also used to treat certain types of cancer including cancers that begin in the tissues that form around a fertilized egg in the uterus, breast cancer, lung cancer, certain cancers of the head and neck, certain types of lymphoma, and leukemia (cancer that begins in the white blood cells).
What is Carditrex 2.5 mg?
Carditrex is an antimetabolite, curative in choriocarcinoma (cancer of the tissue that normally would develop into placenta). It is also used in other cancers like blood, breast and lung cancers. It is also used to suppress immunity in conditions such as psoriasis and rheumatoid arthritis.
How Carditrex 2.5 mg working
Antineoplastic and immunosuppressant antagonist of the ac. folic Interferes in processes of DNA synthesis, repair and cellular replication; It can decrease the development of malignant tissues without irreversible damage in normal tissues.
How is Carditrex 2.5 mg used?
15 to 30 mg IM or orally daily for 5 days. Repeat courses 3 to 5 times with a rest period of greater than or equal to 1 week between courses, until any manifesting toxic symptoms subside.
Effectiveness of therapy is ordinarily evaluated by 24 hour quantitative analysis of urinary chorionic gonadotropin (hCG), which generally will return to normal or less than 50 intl units/24 hours usually after the third or fourth course and usually followed by a complete resolution of measurable lesions in 4 to 6 weeks. One to two courses of Carditrex (25 mg) after normalization of hCG is usually recommended.
Carditrex 2.5 mg Indications
Toxicity increased by: NSAIDs, salicylates, phenylbutazone, phenytoin, sulfonamides, proton pump inhibitors, folate deficiency.
Renal clearance and renal transport reduced by: penicillins, sulfonamides, ciprofloxacin and probenecid.
Intestinal absorption decreased by: tetracyclines, chloramphenicol, broad spectrum antibiotics.
Increased nephrotoxicity with: cisplatin.
Increase plasma levels of: mercaptopurine (requires dose adjustment).
Decreased clearance of: theophylline.
Increased hepatoxicity with: leflunomide, azathioprine, sulfalazine, retinoids.
Increases the risk of pancytopenia with: leflunomide.
Increase risk of soft tissue necrosis and osteonecrosis with: radiotherapy.
Risk of serious neurological adverse reactions with: cytarabine.
Both methotrexate and nitrous oxide alter the metabolism of folate, its concomitant use should be avoided.
Carditrex 2.5 mg Dosage
- Carditrex 2.5 mg
Contraindication Of Carditrex 2.5 mg
Hypersensitivity to methotrexate, pregnancy, lactation, severe IR, severe IH, ulcers of the oral cavity and enf. known active gastrointestinal ulcer, concurrent vaccination with attenuated live microorganism vaccines. Pre-existing blood dyscrasias such as bone marrow depression, leukopenia, thrombocytopenia or significant anemia. Serious, acute or chronic infections such as tuberculosis, HIV or other immunodeficiency syndromes. Alcoholism. Immunodeficiency.
Adverse effects Of Carditrex 2.5 mg
- language disorder,
Special Precautions And Related Warnings Of Carditrex 2.5 mg
IR, IH Risk of fatal toxicity related to involuntary daily rather than weekly administration. Monitoring should be performed to detect toxic effects as soon as possible, complete blood count, platelet differential count, liver enzymes, hepatitis B or C infection tests, renal function tests, chest x-ray and liver biopsy if necessary. . Enf. Neoplasms in women at risk of pregnancy, pregnancy should be avoided between 3 months and 1 year after finishing to.
It can induce s. of tumor lysis, provoke hepatotoxicity, liver fibrosis and cirrhosis, acute or chronic interstitial pneumonitis of noninfectious cause and pleural effusion appear. Risk of myelosuppression, aplastic anemia and gastrointestinal toxicity of severe and unexpected concomitant nature with NSAIDs. Concomitant with radiotherapy may increase the risk of soft tissue necrosis and osteonecrosis. If vomiting, diarrhea or stomatitis occur that result in dehydration, suppress tto. until recovery. Active infection Risk of lethal opportunistic infections, including Pneumocystis carinii pneumonia.
Risk of toxic epidermal necrolysis (S. Lyell), s. of Stevens-Johnson and erythema multiforme. Aggravation of psoriasis lesions due to UV exposure. Radiodermatitis and sunburn injuries prior to the use of methotrexate may reappear with the use of methotrexate.
Safety and efficacy in pediatric patients have only been established in antineoplastic chemotherapy and juvenile idiopathic arthritis of polyarticular evolution. Children <3 years For rheumatologic indications there may be a risk of pulmonary alveolar hemorrhage, which has been associated with vasculitis and other comorbidities. If bronchoscopy with bronchoalveolar lavage and chest x-ray is suspected to confirm the diagnosis.
Storage Conditions for Carditrex 2.5 mg
Store intact vials at room temperature (15-25C). Keep this medication in an airtight container.